DPX Formulations Superior to Mixingwith Commonly Used Adjuvants
DPX Without Antigen Cargo Has Immune StimulatingProperties
Unique Potential for DPX in NewFields of Use
VANCOUVER, BC, December 5, 2024 /CNW/ -- BioVaxys Technology Corp. (CSE: BIOV) (FRA: 5LB)(OTCQB: BVAXF) (“BioVaxys” or the Company”) presented a new study today at the Personalized Cancer Vaccine Summit (formerly known as the mRNA Cancer VaccineSummit) in Boston, MA, that supports further differentiation of its DPX immune educating platform from current aqueous, emulsion, and LNP antigen delivery systems. The study demonstrates that DPX formulations with tumor-derived peptide neoantigens are highly effective vaccines to inhibit or prevent tumor growth following tumor challenges. DPX formulations were more effective than mixing with commonly used adjuvants, and DPX formulations were demonstrated to be as effective as the gold standard, bone marrow-derived dendritic cells. A highly significant result of the study is DPX formulations (with a checkpoint inhibitor) without a packaged cargo peptide appear to have meaningful immune stimulating properties on their own.
BioVaxys’ DPX™ technology(“DPX”) is a patented delivery platform that can incorporate a range of bioactive molecules, such as mRNA/polynucleotides, peptides/proteins, virus-like particles, and small molecules, to produce targeted, long-lasting immune responses enabled by various formulated components. The DPX platform, which is non-aqueous and non-systemic, facilitates antigen delivery to regional lymph nodes and has been demonstrated to induce robust and durable T cell and B cell responses in pre-clinical and clinical studies for both cancer and infectious disease.
David Berd, MD,Chief Medical Officer of BioVaxys, delivered the keynote presentation entitled “A Novel Delivery System for Personalized Peptide & mRNA Vaccines for More Targeted Therapies” based on studies of tumor neopeptides conducted by Hakimeh Ebrahimi-Nik, DVM, PhD, of The Ohio State University Comprehensive Cancer Center and Pelotonia Institute for Immuno-Oncology, where her team studies the molecular mechanisms that enhance immune responses against tumors.
Dr. Nik’s study utilized the Meth A mouse tumor model, a widely used experimental model in cancer research. Novel, tumor-specific peptides (neopeptides) were identified and biomanufactured using standard molecular techniques. Several peptides served as effective vaccines when injected with bone marrow-derived dendritic cells. Administration of these vaccines prior to a challenge with live Meth A sarcoma cells completely or partially prevented tumor growth, while vaccines composed of non-protective peptides did not. Dr. Nik then tested the immunoprotective properties of DPX formulations, made by incorporating a rejection peptide, Neo1, into the DPX formulation. To make the vaccine more potent the drug 9D9---a checkpoint inhibitor---was administered with the vaccine. DPX-Neo1 plus 9D9 was found to be as effective in preventing tumor growth as the standard Neo1 + dendritic cells vaccine.
Studies with another rejecting peptide, Tfdpa, showed even more striking results. The DPX-peptide formulation provided better protection against tumor growth than the Tfdpa + dendritic cell vaccine. Of high importance, in these experiments DPX without a peptide antigen cargo + 9D9 showed a significant immunoprotecting effect on its own.
The study also compared the immunoprotecting effect of DPX+peptide antigen with vaccines consisting of peptide mixed with the commonly used immunological adjuvants Montanide (a water-in-oil emulsion mixed with water based antigen), AddaVax (a squalene-based oil-in-water nano-emulsion), and TiterMax (copolymers, squalene, and a stabilizer), with DPX formulations shown to be more effective than any of these popular adjuvants.
BioVaxys President and Chief Operating Officer Kenneth Kovan stated “This study extends the commercial utility of the DPX platform to the high potential field of tumor neopeptides, with resulting implications for the development of human personalized cancer vaccines and use as a vaccine adjuvant.”
The global vaccine adjuvants market was USD 1,350.6 million in 2022 and is forecast to reach USD 2,950.57 million by 2030 with a CAGR of 13.37%. Factors such as the increasing prevalence of Infectious Disease, expanding vaccination programs, and advancements in adjuvant development are driving market expansion. Additionally, the growing focus on developing vaccines for emerging diseases and the need for improved vaccine efficacy and safety further contribute to market growth1.
(1) Databridge MarketResearch (2023)
About BioVaxys Technology Corp.
BioVaxys Technology Corp. (www.biovaxys.com)is a clinical-stage biopharmaceutical company dedicated to improving patient lives with novel immunotherapies based on its DPX™ immune-educating technology platform and its HapTenix© "neoantigen" tumor cell construct platform, for treating cancers, infectious disease, antigen desensitization for food allergy, and other immunological diseases. Through a differentiated mechanism of action, the DPX™ platform delivers instruction to the immune system to generate a specific, robust, and persistent immune response. The Company's clinical stage pipeline includes maveropepimut-S (MVP-S), based on the DPX™ platform, and is in Phase II B clinical development for advanced Relapsed-Refractory Diffuse Large B Cell Lymphoma (DLBCL) and platinum resistant Ovarian Cancer. MVP-S delivers antigenic peptides from survivin, a well-recognized cancer antigen commonly over expressed in advanced cancers, and also delivers an innate immune activator and a universal CD4 T cell helper peptide. MVP-S has been well tolerated and has demonstrated defined clinical benefit in multiple cancer indications as well as the activation of a targeted and sustained, survivin-specific anti-tumor immune response. BioVaxys is also developing DPX™+SurMAGE, a dual-targeted immunotherapy combining antigenic peptides for both the survivin and MAGE-A9 cancer proteins to elicit immune responses to these two distinct cancer antigens simultaneously, DPX™-RSV for Respiratory Syncytial Virus, DPX+rPA for peanut allergy prophylaxis, and BVX-0918, a personalized immunotherapeutic vaccine using its proprietary HapTenix© "neoantigen" tumor cell construct platform for refractive late-stage ovarian cancer. BioVaxys common shares are listed on the CSE under the stock symbol "BIOV", trade on the Frankfurt Bourse (FRA: 5LB),and in the US (OTCQB:BVAXF). For more information, visit www.biovaxys.com and connect with us on X and LinkedIn.
ON BEHALF OF THE BOARD
Signed "James Passin"
James Passin, Chief Executive Officer
Phone: +1 740 358 0555
Email: jpassin@biovaxys.com
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